Nanomechanics of Ankyrin Repeat Proteins
نویسندگان
چکیده
Nanomechanics of Ankyrin Repeat Proteins
منابع مشابه
Mutation of Conserved Histidines Alters Tertiary Structure and Nanomechanics of Consensus Ankyrin Repeats*
The conserved TPLH tetrapeptide motif of ankyrin repeats (ARs) plays an important role in stabilizing AR proteins, and histidine (TPLH)-to-arginine (TPLR) mutations in this motif have been associated with a hereditary human anemia, spherocytosis. Here, we used a combination of atomic force microscopy-based single-molecule force spectroscopy and molecular dynamics simulations to examine the mech...
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Ankyrin repeat, one of the most widely existing protein motifs in nature, consists of 30-34 amino acid residues and exclusively functions to mediate protein-protein interactions, some of which are directly involved in the development of human cancer and other diseases. Each ankyrin repeat exhibits a helix-turn-helix conformation, and strings of such tandem repeats are packed in a nearly linear ...
متن کاملAnchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiology
The ankyrin repeat is a protein module with high affinity for other ankyrin repeats based on strong Van der Waals forces. The resulting dimerization is unusually resistant to both mechanical forces and alkanization, making this module exceedingly useful for meeting the extraordinary demands of muscle physiology. Many aspects of muscle function are controlled by the superfamily ankyrin repeat do...
متن کاملConsensus-derived structural determinants of the ankyrin repeat motif.
The ankyrin repeat is one of the most common, modular, protein-protein interaction motifs in nature. To understand the structural determinants of this family of proteins and extract the consensus information that defines the architecture of this motif, we have designed a series of idealized ankyrin repeat proteins containing one, two, three, or four repeats by using statistical analysis of appr...
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The ability of the IkBa protein to sequester dimeric NF-kB/Rel proteins in the cytoplasm provides an effective mechanism for regulating the potent transcriptional activation properties of NF-kB/Rel family members. IkBa can also act in the nucleus as a postinduction repressor of NF-kB/Rel proteins. The mechanism by which IkBa enters the nucleus is not known, as IkBa lacks a discernible classical...
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